2025 MLS Season Preview: Odds and Favorites for MLS Cup and Conference Titles
By BetOnline
March 3, 2025
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The 2025 MLS season gets underway on Saturday.
After leading the MLS with 74 points last year and being the favorite all season long to bring home the MLS Cup, Lionel Messi and Inter Miami CF lost in the first round of the playoffs to Atlanta United FC.
It’s Messi’s second full season in the MLS and despite falling way short last year, they are once again the favorites at BetOnline.ag.
The odds below are subject to change, here’s the direct link to real-time lines: https://www.betonline.ag/sportsbook/futures-and-props/soccer-futures/major-league-soccer.
| 2025 MLS Cup Champion | ||
| Inter Miami FC | 4/1 | |
| Los Angeles FC | 13/2 | (+650) |
| FC Cincinnati | 10/1 | |
| Columbus Crew | 11/1 | |
| Los Angeles Galaxy | 12/1 | |
| New York Red Bulls | 16/1 | |
| Atlanta United | 18/1 | |
| Seattle Sounders | 18/1 | |
| Orlando City SC | 20/1 | |
| New York City FC | 22/1 | |
| Houston Dynamo | 25/1 | |
| Philadelphia Union | 25/1 | |
| Vancouver Whitecaps | 25/1 | |
| Real Salt Lake | 28/1 | |
| Minnesota United | 35/1 | |
| Charlotte FC | 45/1 | |
| San Diego FC | 45/1 | |
| Austin FC | 50/1 | |
| Colorado Rapids | 50/1 | |
| D.C. United | 50/1 | |
| FC Dallas | 50/1 | |
| Nashville SC | 50/1 | |
| Portland Timbers | 50/1 | |
| St. Louis City SC | 50/1 | |
| New England Revolution | 66/1 | |
| San Jose Earthquakes | 66/1 | |
| Sporting Kansas City | 66/1 | |
| Toronto FC | 66/1 | |
| CF Montreal | 80/1 | |
| Chicago Fire | 80/1 | |
| Conference Odds | ||
| 2025 Eastern Conference Champion | ||
| Inter Miami FC | 2/1 | |
| FC Cincinnati | 5/1 | |
| Columbus Crew | 11/2 | (+550) |
| New York Red Bulls | 17/2 | (+850) |
| Atlanta United | 9/1 | |
| New York City FC | 12/1 | |
| Orlando City SC | 12/1 | |
| Philadelphia Union | 14/1 | |
| Charlotte FC | 18/1 | |
| Nashville SC | 28/1 | |
| D.C. United | 35/1 | |
| CF Montreal | 35/1 | |
| Chicago Fire | 45/1 | |
| New England Revolution | 45/1 | |
| Toronto FC | 45/1 | |
| 2025 Western Conference Champion | ||
| Los Angeles FC | 5/2 | (+250) |
| Los Angeles Galaxy | 5/1 | |
| Seattle Sounders | 15/2 | (+750) |
| Minnesota United | 10/1 | |
| Houston Dynamo | 12/1 | |
| Real Salt Lake | 12/1 | |
| Vancouver Whitecaps | 12/1 | |
| Austin FC | 18/1 | |
| Colorado Rapids | 18/1 | |
| Portland Timbers | 20/1 | |
| San Diego FC | 20/1 | |
| FC Dallas | 22/1 | |
| St. Louis City SC | 25/1 | |
| San Jose Earthquakes | 28/1 | |
| Sporting Kansas City | 30/1 | |
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